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C3 Antibody (C-term)

Mouse Monoclonal Antibody (Mab)

     
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  • 1 - C3 Antibody (C-term) AM2085a
    All lanes : Anti-C3 Antibody (C-term) at 1:2000 dilution Lane 1: Hela whole cell lysate Lane 2: HepG2 whole cell lysate Lane 3: K562 whole cell lysate Lane 4: CCRF-CEM whole cell lysate Lane 5: MDA-MB-453 whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-mouse IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 187 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, E
Primary Accession P01024
Other Accession NP_000055.2
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype IgG1
Clone Names 567CT11.2.3
Calculated MW 187148 Da
Additional info
Gene ID 718
Other Names Complement C3, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1, Complement C3 beta chain, C3-beta-c, C3bc, Complement C3 alpha chain, C3a anaphylatoxin, Acylation stimulating protein, ASP, C3adesArg, Complement C3b alpha' chain, Complement C3c alpha' chain fragment 1, Complement C3dg fragment, Complement C3g fragment, Complement C3d fragment, Complement C3f fragment, Complement C3c alpha' chain fragment 2, C3, CPAMD1
Target/Specificity This C3 antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 1353-1382 amino acids from the C-terminal region of human C3.
Dilution WB~~1:2000
Format Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsC3 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name C3
Synonyms CPAMD1
Function C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates. C3-beta-c: Acts as a chemoattractant for neutrophils in chronic inflammation.
Cellular Location Secreted.
Tissue Location Plasma. The acylation stimulating protein (ASP) is expressed in adipocytes and released into the plasma during both the fasting and postprandial periods
Research Areas

BACKGROUND

Complement component C3 plays a central role in the activation of complement system. Its activation is required for both classical and alternative complement activation pathways. People with C3 deficiency are susceptible to bacterial infection.

REFERENCES

Martinez-Barricarte, R., et al. J. Clin. Invest. 120(10):3702-3712(2010)
Ruan, B.H., et al. J. Immunol. 185(7):4213-4222(2010)
Luo, S., et al. J. Immunol. 185(4):2164-2173(2010)
Zerbib, J., et al. Mol. Vis. 16, 1324-1330 (2010) :
Johnatty, S.E., et al. PLoS Genet. 6 (7), E1001016 (2010) :

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