|Application ||WB, E|
|Calculated MW||21307 Da|
|Other Names||Erythropoietin, Epoetin, EPO|
|Target/Specificity||Purified His-tagged EPO protein(Fragment) was used to produced this monoclonal antibody.|
|Format||Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||EPO Antibody (Ascites) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3.|
|Tissue Location||Produced by kidney or liver of adult mammals and by liver of fetal or neonatal mammals|
Provided below are standard protocols that you may find useful for product applications.
This gene is a member of the EPO/TPO family and encodes a secreted, glycosylated cytokine composed of four alpha helical bundles. The protein is found in the plasma and regulates red cell production by promoting erythroid differentiation and initiating hemoglobin synthesis. This protein also has neuroprotective activity against a variety of potential brain injuries and antiapoptotic functions in several tissue types. [provided by RefSeq].
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Carraway, M.S., et al. Circ. Res. 106(11):1722-1730(2010)
Shi, Z., et al. Mol. Cancer Res. 8(4):615-626(2010)