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HMG2 Antibody (Ascites)

Mouse Monoclonal Antibody (Mab)

     
  • 1 - HMG2 Antibody (Ascites) AM2077a
    HMG2 Antibody (Cat. #AM2077a) western blot analysis in HepG2 cell line lysates (35μg/lane).This demonstrates the HMG2 antibody detected the HMG2 protein (arrow).
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, E
Primary Accession P52926
Other Accession P52927, NP_003474.1
Reactivity Human
Predicted Mouse
Host Mouse
Clonality Monoclonal
Isotype IgG2b
Clone Names 523ct16.1.1
Calculated MW 11832 Da
Additional info
Gene ID 8091
Other Names High mobility group protein HMGI-C, High mobility group AT-hook protein 2, HMGA2, HMGIC
Target/Specificity This HMG2 antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 64-92 amino acids from human HMG2.
Dilution WB~~1:500~8000
Format Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsHMG2 Antibody (Ascites) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name HMGA2
Synonyms HMGIC
Function Functions as a transcriptional regulator. Functions in cell cycle regulation through CCNA2. Plays an important role in chromosome condensation during the meiotic G2/M transition of spermatocytes.
Cellular Location Nucleus.
Research Areas

BACKGROUND

This gene encodes a protein that belongs to the non-histone chromosomal high mobility group (HMG) protein family. HMG proteins function as architectural factors and are essential components of the enhancesome. This protein contains structural DNA-binding domains and may act as a transcriptional regulating factor. Identification of the deletion, amplification, and rearrangement of this gene that are associated with myxoid liposarcoma suggests a role in adipogenesis and mesenchymal differentiation. A gene knock out study of the mouse counterpart demonstrated that this gene is involved in diet-induced obesity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

REFERENCES

Markowski, D.N., et al. Cancer Genet. Cytogenet. 202(1):53-57(2010)
Velagaleti, G.V., et al. Cancer Genet. Cytogenet. 202(1):11-16(2010)
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Liu, Y., et al. Carcinogenesis 31(10):1762-1769(2010)
Voight, B.F., et al. Nat. Genet. 42(7):579-589(2010)

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