|Application ||WB, E|
|Other Accession||P52927, NP_003474.1|
|Calculated MW||11832 Da|
|Other Names||High mobility group protein HMGI-C, High mobility group AT-hook protein 2, HMGA2, HMGIC|
|Target/Specificity||This HMG2 antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 64-92 amino acids from human HMG2.|
|Format||Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||HMG2 Antibody (Ascites) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Functions as a transcriptional regulator. Functions in cell cycle regulation through CCNA2. Plays an important role in chromosome condensation during the meiotic G2/M transition of spermatocytes. Plays a role in postnatal myogenesis, is involved in satellite cell activation (By similarity).|
Provided below are standard protocols that you may find useful for product applications.
This gene encodes a protein that belongs to the non-histone chromosomal high mobility group (HMG) protein family. HMG proteins function as architectural factors and are essential components of the enhancesome. This protein contains structural DNA-binding domains and may act as a transcriptional regulating factor. Identification of the deletion, amplification, and rearrangement of this gene that are associated with myxoid liposarcoma suggests a role in adipogenesis and mesenchymal differentiation. A gene knock out study of the mouse counterpart demonstrated that this gene is involved in diet-induced obesity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
Markowski, D.N., et al. Cancer Genet. Cytogenet. 202(1):53-57(2010)
Velagaleti, G.V., et al. Cancer Genet. Cytogenet. 202(1):11-16(2010)
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Liu, Y., et al. Carcinogenesis 31(10):1762-1769(2010)
Voight, B.F., et al. Nat. Genet. 42(7):579-589(2010)