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FCGR3A Antibody (Ascites)

Mouse Monoclonal Antibody (Mab)

     
  • 1 - FCGR3A Antibody (Ascites) AM2044a
    FCGR3A Antibody (Cat. #AM2044a) western blot analysis in CEM cell line lysates (35μg/lane).This demonstrates the FCGR3A antibody detected the FCGR3A protein (arrow).
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, E
Primary Accession P08637
Other Accession NP_000560.5
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype IgG1
Clone Names 441CT4.2.1
Calculated MW 29089 Da
Additional info
Gene ID 2214
Other Names Low affinity immunoglobulin gamma Fc region receptor III-A, CD16a antigen, Fc-gamma RIII-alpha, Fc-gamma RIII, Fc-gamma RIIIa, FcRIII, FcRIIIa, FcR-10, IgG Fc receptor III-2, CD16a, FCGR3A, CD16A, FCG3, FCGR3, IGFR3
Target/Specificity This FCGR3A antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 60-88 amino acids from human FCGR3A.
Dilution WB~~1:100~400
Format Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsFCGR3A Antibody (Ascites) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name FCGR3A
Synonyms CD16A, FCG3, FCGR3, IGFR3
Function Receptor for the Fc region of IgG. Binds complexed or aggregated IgG and also monomeric IgG. Mediates antibody-dependent cellular cytotoxicity (ADCC) and other antibody-dependent responses, such as phagocytosis.
Cellular Location Cell membrane; Single-pass type I membrane protein. Secreted. Note=Exists also as a soluble receptor
Tissue Location Expressed on natural killer cells, macrophages, subpopulation of T-cells, immature thymocytes and placental trophoblasts
Research Areas

BACKGROUND

This gene encodes a receptor for the Fc portion of immunoglobulin G, and it is involved in the removal of antigen-antibody complexes from the circulation, as well as other other antibody-dependent responses. This gene (FCGR3A) is highly similar to another nearby gene (FCGR3B) located on chromosome 1. The receptor encoded by this gene is expressed on natural killer (NK) cells as an integral membrane glycoprotein anchored through a transmembrane peptide, whereas FCGR3B is expressed on polymorphonuclear neutrophils (PMN) where the receptor is anchored through a phosphatidylinositol (PI) linkage. Mutations in this gene have been linked to susceptibility to recurrent viral infections, susceptibility to systemic lupus erythematosus, and alloimmune neonatal neutropenia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

REFERENCES

Dornan, D., et al. Blood 116(20):4212-4222(2010)
Li, S.C., et al. Am. J. Hematol. 85(10):810-812(2010)
Iwasaki, M., et al. Breast Cancer Res. Treat. (2010) In press :
Qu, Y.H., et al. Zhongguo Shi Yan Xue Ye Xue Za Zhi 18(4):959-962(2010)
Sfar, I., et al. Arch Inst Pasteur Tunis 86 (1-4), 51-62 (2009) :

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