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>   首页   >   产品   >   一抗   >   神经科学   >   RAB23 Antibody   

RAB23 Antibody

Mouse Monoclonal Antibody (Mab)

     
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, IF, FC, E
Primary Accession Q9ULC3
Other Accession NP_899050.1, NP_057361.3
Reactivity Human, Mouse
Host Mouse
Clonality Monoclonal
Isotype IgG1
Clone Names 427CT2.1.1
Additional info
Gene ID 51715
Other Names Ras-related protein Rab-23, RAB23
Target/Specificity Purified His-tagged RAB23 protein(Fragment) was used to produced this monoclonal antibody.
Format Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsRAB23 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name RAB23
Function The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Together with SUFU, prevents nuclear import of GLI1, and thereby inhibits GLI1 transcription factor activity. Regulates GLI1 in differentiating chondrocytes. Likewise, regulates GLI3 proteolytic processing and modulates GLI2 and GLI3 transcription factor activity. Plays a role in autophagic vacuole assembly, and mediates defense against pathogens, such as S.aureus, by promoting their capture by autophagosomes that then merge with lysosomes.
Cellular Location Cell membrane; Lipid-anchor; Cytoplasmic side. Cell membrane Cytoplasm. Cytoplasmic vesicle, autophagosome. Endosome membrane. Cytoplasmic vesicle, phagosome. Cytoplasmic vesicle, phagosome membrane; Lipid-anchor; Cytoplasmic side. Note=Recruited to phagosomes containing S.aureus or M.tuberculosis
Research Areas

BACKGROUND

The protein encoded by this gene belongs to the small GTPase superfamily, Rab family. It may be involved in small GTPase mediated signal transduction and intracellular protein transportation. Alternative splicing occurs at this locus and two transcript variants encoding the same protein have been identified.

REFERENCES

Alessandri, J.L., et al. Am. J. Med. Genet. A 152A (4), 982-986 (2010) :
Hou, Q., et al. Cancer Res. 68(12):4623-4630(2008)
Ng, E.L., et al. Brain Res Rev 58(1):236-246(2008)
Jenkins, D., et al. Am. J. Hum. Genet. 80(6):1162-1170(2007)
Liu, Y.J., et al. World J. Gastroenterol. 13(7):1010-1017(2007)

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