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>   首页   >   产品   >   一抗   >   信号转导   >   NCOA4 Antibody(Ascites)   

NCOA4 Antibody(Ascites)

Mouse Monoclonal Antibody (Mab)

     
  • 1 - NCOA4 Antibody(Ascites) AM2019a
    NCOA4 Antibody (Cat. #AM2019a) western blot analysis in 293 cell line lysates (35μg/lane).This demonstrates the NCOA4 antibody detected the NCOA4 protein (arrow).
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, E
Primary Accession Q13772
Other Accession NP_001138734.1, NP_001138732.1
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype IgM
Clone Names 439CT10.4.4
Calculated MW 69726 Da
Additional info
Gene ID 8031
Other Names Nuclear receptor coactivator 4, NCoA-4, Androgen receptor coactivator 70 kDa protein, 70 kDa AR-activator, 70 kDa androgen receptor coactivator, Androgen receptor-associated protein of 70 kDa, Ret-activating protein ELE1, NCOA4, ARA70, ELE1, RFG
Target/Specificity Purified His-tagged NCOA4 protein(Fragment) was used to produced this monoclonal antibody.
Dilution WB~~1:500~3200
Format Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsNCOA4 Antibody(Ascites) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name NCOA4
Synonyms ARA70, ELE1, RFG
Function Enhances the androgen receptor transcriptional activity in prostate cancer cells. Ligand-independent coactivator of the peroxisome proliferator-activated receptor (PPAR) gamma.
Tissue Location Widely expressed. Also detected in adipose tissues and in different cell lines. Isoform Beta is only expressed in testis
Research Areas

BACKGROUND

This gene encodes an androgen receptor coactivator. The encoded protein interacts with the androgen receptor in a ligand-dependent manner to enhance its transcriptional activity. Chromosomal translocations between this gene and the ret tyrosine kinase gene, also located on chromosome 10, have been associated with papillary thyroid carcinoma. Alternatively spliced transcript variants have been described. Pseudogenes are present on chromosomes 4, 5, 10, and 14.

REFERENCES

Sadow, P.M., et al. Endocr. Pathol. 21(2):73-79(2010)
Landa, I., et al. PLoS Genet. 5 (9), E1000637 (2009) :
Richardson, D.S., et al. Cancer Res. 69(11):4861-4869(2009)
Peng, Y., et al. Am. J. Pathol. 172(1):225-235(2008)
Bongarzone, I., et al. Genomics 42(2):252-259(1997)

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