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TLE4 Antibody (Center)

Mouse Monoclonal Antibody (Mab)

     
  • 1 - TLE4 Antibody (Center) AM2017b
    TLE4 Antibody (Center) (Cat. #AM2017b) western blot analysis in NCI-H460 cell line lysates (35μg/lane).This demonstrates the TLE4 antibody detected the TLE4 protein (arrow).
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, E
Primary Accession Q04727
Other Accession Q07141, Q62441, NP_008936.2
Reactivity Human
Predicted Mouse, Rat
Host Mouse
Clonality Monoclonal
Isotype IgM
Clone Names 384CT24.1.3.4
Calculated MW 83755 Da
Additional info
Gene ID 7091
Other Names Transducin-like enhancer protein 4, Grg-4, Groucho-related protein 4, TLE4, GRG4, KIAA1261
Target/Specificity This TLE4 antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 262-290 amino acids from the Central region of human TLE4.
Dilution WB~~1:100~250
Format Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Euglobin precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsTLE4 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TLE4
Synonyms GRG4, KIAA1261
Function Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by PAX5, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Essential for the transcriptional repressor activity of SIX3 during retina and lens development and for SIX3 transcriptional auto-repression (By similarity).
Cellular Location Nucleus.
Tissue Location In all tissues examined, mostly in brain, and muscle
Research Areas

BACKGROUND

Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by PAX5, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES (By similarity).

REFERENCES

Liu, Y., et al. PLoS Genet. 5 (11), E1000707 (2009) :
Hancock, D.B., et al. PLoS Genet. 5 (8), E1000623 (2009) :
Stolk, L., et al. Nat. Genet. (2009) In press :
Dayyani, F., et al. Blood 111(8):4338-4347(2008)
Heimbucher, T., et al. Mol. Cell. Biol. 27(1):340-351(2007)

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