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>   首页   >   产品   >   一抗   >   信号转导   >   ITGAX/CD11c Antibody (N-term)   

ITGAX/CD11c Antibody (N-term)

Mouse Monoclonal Antibody (Mab)

     
  • 1 - ITGAX/CD11c Antibody (N-term) AM2013b
    ITGAX/CD11c Antibody (N-term) (Cat. #AM2013b) western blot analysis in ZR-75-1 cell line lysates (35μg/lane).This demonstrates the ITGAX/CD11c antibody detected the ITGAX/CD11c protein (arrow).
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, E
Primary Accession P20702
Other Accession NP_000878.2
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype IgG1
Clone Names 428CT12.2.6.4
Calculated MW 127829 Da
Additional info
Gene ID 3687
Other Names Integrin alpha-X, CD11 antigen-like family member C, Leu M5, Leukocyte adhesion glycoprotein p150, 95 alpha chain, Leukocyte adhesion receptor p150, CD11c, ITGAX, CD11C
Target/Specificity This ITGAX/CD11c antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 246-274 amino acids from the N-terminal region of human ITGAX/CD11c.
Dilution WB~~1:100~500
Format Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsITGAX/CD11c Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ITGAX
Synonyms CD11C
Function Integrin alpha-X/beta-2 is a receptor for fibrinogen. It recognizes the sequence G-P-R in fibrinogen. It mediates cell-cell interaction during inflammatory responses. It is especially important in monocyte adhesion and chemotaxis.
Cellular Location Membrane; Single-pass type I membrane protein
Tissue Location Predominantly expressed in monocytes and granulocytes
Research Areas

BACKGROUND

This gene encodes the integrin alpha X chain protein. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as inactivated-C3b (iC3b) receptor 4 (CR4). The alpha X beta 2 complex seems to overlap the properties of the alpha M beta 2 integrin in the adherence of neutrophils and monocytes to stimulated endothelium cells, and in the phagocytosis of complement coated particles.

REFERENCES

Van Brussel, I., et al. J. Immunol. Methods 362 (1-2), 168-175 (2010) :
Chen, X., et al. Proc. Natl. Acad. Sci. U.S.A. 107(33):14727-14732(2010)
Lindsay, R.W., et al. J. Immunol. 185(3):1513-1521(2010)
Kraus, T.S., et al. Am. J. Clin. Pathol. 134(2):271-277(2010)
Quist, S.R., et al. Acta Derm. Venereol. 90(4):429-430(2010)

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