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>   首页   >   产品   >   一抗   >   神经科学   >   GJC2 Antibody (N-term)   

GJC2 Antibody (N-term)

Mouse Monoclonal Antibody (Mab)

     
  • 1 - GJC2 Antibody (N-term) AM1998b
    GJC2 Antibody (N-term) (Cat. #AM1998b ) western blot analysis in A549 cell line lysates (35μg/lane).This demonstrates the GJC2 antibody detected the GJC2 protein (arrow).
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, E
Primary Accession Q5T442
Other Accession NP_065168.2
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype IgM
Clone Names 391CT6.4.3
Calculated MW 47002 Da
Additional info
Gene ID 57165
Other Names Gap junction gamma-2 protein, Connexin-466, Cx466, Connexin-47, Cx47, Gap junction alpha-12 protein, GJC2, GJA12
Target/Specificity This GJC2 antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 32-61 amino acids from the N-terminal region of human GJC2.
Dilution WB~~1:100~500
Format Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Euglobin precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGJC2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name GJC2
Synonyms GJA12
Function One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. May play a role in myelination in central and peripheral nervous systems.
Cellular Location Cell membrane; Multi-pass membrane protein. Cell junction, gap junction
Tissue Location Expressed in central nervous system, in sciatic nerve and sural nerve. Also detected in skeletal muscles
Research Areas

BACKGROUND

GJC2 is a gap junction protein. Gap junction proteins are members of a large family of homologous connexins and comprise 4 transmembrane, 2 extracellular, and 3 cytoplasmic domains. This gene plays a key role in central myelination and is involved in peripheral myelination in humans. Defects in this gene are the cause of autosomal recessive Pelizaeus-Merzbacher-like disease-1.

REFERENCES

Ferrell, R.E., et al. Am. J. Hum. Genet. 86(6):943-948(2010)
Wang, J., et al. Brain Dev. 32(3):236-243(2010)
Ishikawa, T., et al. Rinsho Shinkeigaku 50(1):7-11(2010)
Ruf, N., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 150B (2), 226-232 (2009) :
Orthmann-Murphy, J.L., et al. Brain 132 (PT 2), 426-438 (2009) :

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