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GJC2 Antibody (N-term)(Ascites)

Mouse Monoclonal Antibody (Mab)

     
  • 1 - GJC2 Antibody (N-term)(Ascites) AM1998a
    GJC2 Antibody (N-term) (Cat. #AM1998a) western blot analysis in A549 cell line lysates (35μg/lane).This demonstrates the GJC2 antibody detected the GJC2 protein (arrow).
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, E
Primary Accession Q5T442
Other Accession Q80XF7, Q8BQU6, Q29RK8, Q7ZXS7, A4GG66, A4GVD1, P28229, P36383, Q92052, Q6R4A8, P18861, Q2HJ66, NP_065168.2
Reactivity Human
Predicted Bovine, Chicken, Hamster, Zebrafish, Mouse, Pig, Rat, Xenopus
Host Mouse
Clonality Monoclonal
Isotype IgM
Clone Names 391CT6.4.3
Calculated MW 47002 Da
Additional info
Gene ID 57165
Other Names Gap junction gamma-2 protein, Connexin-466, Cx466, Connexin-47, Cx47, Gap junction alpha-12 protein, GJC2, GJA12
Target/Specificity This GJC2 antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 53-78 amino acids from the N-terminal region of human GJC2.
Dilution WB~~1:100~8000
Format Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGJC2 Antibody (N-term)(Ascites) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name GJC2
Synonyms GJA12
Function One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. May play a role in myelination in central and peripheral nervous systems.
Cellular Location Cell membrane; Multi-pass membrane protein. Cell junction, gap junction
Tissue Location Expressed in central nervous system, in sciatic nerve and sural nerve. Also detected in skeletal muscles
Research Areas

BACKGROUND

GJC2 is a gap junction protein. Gap junction proteins are members of a large family of homologous connexins and comprise 4 transmembrane, 2 extracellular, and 3 cytoplasmic domains. This gene plays a key role in central myelination and is involved in peripheral myelination in humans. Defects in this gene are the cause of autosomal recessive Pelizaeus-Merzbacher-like disease-1.

REFERENCES

Ferrell, R.E., et al. Am. J. Hum. Genet. 86(6):943-948(2010)
Wang, J., et al. Brain Dev. 32(3):236-243(2010)
Ishikawa, T., et al. Rinsho Shinkeigaku 50(1):7-11(2010)
Ruf, N., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 150B (2), 226-232 (2009) :
Orthmann-Murphy, J.L., et al. Brain 132 (PT 2), 426-438 (2009) :

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