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>   首页   >   产品   >   一抗   >   心血管   >   T Antibody   

T Antibody

Mouse Monoclonal Antibody (Mab)

     
  • 1 - T Antibody AM1993b
    T Antibody (Cat. #AM1993b) western blot analysis in mouse kidney tissue lysates (35μg/lane).This demonstrates the T antibody detected the T protein (arrow).
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, E
Primary Accession O15178
Other Accession NP_003172.1
Reactivity Human, Mouse
Host Mouse
Clonality Monoclonal
Isotype IgM
Clone Names 394CT14.1.4
Calculated MW 47443 Da
Additional info
Gene ID 6862
Other Names Brachyury protein, Protein T, T
Target/Specificity This T antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 262-291 amino acids from human T.
Dilution WB~~1:100~250
Format Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Euglobin precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsT Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TBXT (HGNC:11515)
Synonyms T
Function Involved in the transcriptional regulation of genes required for mesoderm formation and differentiation. Binds to a palindromic site (called T site) and activates gene transcription when bound to such a site.
Cellular Location Nucleus
Tissue Location Detected in testis, but not in other, normal tissues. Detected in lung tumors (at protein level)
Research Areas

BACKGROUND

The protein encoded by this gene is an embryonic nuclear transcription factor that binds to a specific DNA element, the palindromic T-site. It binds through a region in its N-terminus, called the T-box, and effects transcription of genes required for mesoderm formation and differentiation. The protein is localized to notochord-derived cells.

REFERENCES

Jambhekar, N.A., et al. Arch. Pathol. Lab. Med. 134(8):1181-1187(2010)
Docherty, S.J., et al. BMC Genet. 11, 61 (2010) :
Yang, X.R., et al. Nat. Genet. 41(11):1176-1178(2009)
Oakley, G.J., et al. Mod. Pathol. 21(12):1461-1469(2008)
Bondue, A., et al. Cell Stem Cell 3(1):69-84(2008)

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