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THAP11 Antibody (Center)

Mouse Monoclonal Antibody (Mab)

     
  • 1 - THAP11 Antibody (Center) AM1984b
    THAP11 Antibody (Center) (Cat. #AM1984b) western blot analysis in HepG2 cell line lysates (35μg/lane).This demonstrates the THAP11 antibody detected the THAP11 protein (arrow).
  • 1 - THAP11 Antibody (Center) AM1984b
    THAP11 Antibody (Center) (Cat. #AM1984b) western blot analysis in mouse NIH-3T3 cell line lysates (35μg/lane).This demonstrates the THAP11 antibody detected the THAP11 protein (arrow).
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, E
Primary Accession Q96EK4
Other Accession A5PKF5, NP_065190.2
Reactivity Human, Mouse
Predicted Bovine
Host Mouse
Clonality Monoclonal
Isotype IgM
Clone Names 364CT25.4.2
Calculated MW 34455 Da
Additional info
Gene ID 57215
Other Names THAP domain-containing protein 11, THAP11
Target/Specificity This THAP11 antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 165-193 amino acids from the Central region of human THAP11.
Dilution WB~~1:100~500
Format Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Euglobin precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsTHAP11 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name THAP11
Function Transcriptional repressor that plays a central role for embryogenesis and the pluripotency of embryonic stem (ES) cells. Sequence-specific DNA-binding factor that represses gene expression in pluripotent ES cells by directly binding to key genetic loci and recruiting epigenetic modifiers (By similarity).
Cellular Location Nucleus. Cytoplasm. Note=May be regulated by shuttling of the protein between the cytoplasm and nucleus.
Research Areas

BACKGROUND

The protein encoded by this gene contains a THAP domain, which is a conserved DNA-binding domain that has striking similarity to the site-specific DNA-binding domain (DBD) of Drosophila P element transposases.

REFERENCES

Zhu, C.Y., et al. Cell Death Differ. 16(3):395-405(2009)
Dejosez, M., et al. Cell 133(7):1162-1174(2008)
Roussigne, M., et al. Trends Biochem. Sci. 28(2):66-69(2003)
Ueki, N., et al. Nat. Biotechnol. 16(13):1338-1342(1998)
Li, S.H., et al. Genomics 16(3):572-579(1993)

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