|Application ||WB, E|
|Other Accession||A5PKF5, NP_065190.2|
|Other Names||THAP domain-containing protein 11, THAP11|
|Target/Specificity||This THAP11 antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 165-193 amino acids from the Central region of human THAP11.|
|Format||Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||THAP11 Antibody (Center) (Ascites) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Transcriptional repressor that plays a central role for embryogenesis and the pluripotency of embryonic stem (ES) cells. Sequence-specific DNA-binding factor that represses gene expression in pluripotent ES cells by directly binding to key genetic loci and recruiting epigenetic modifiers (By similarity).|
|Cellular Location||Nucleus. Cytoplasm. Note=May be regulated by shuttling of the protein between the cytoplasm and nucleus.|
Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene contains a THAP domain, which is a conserved DNA-binding domain that has striking similarity to the site-specific DNA-binding domain (DBD) of Drosophila P element transposases.
Zhu, C.Y., et al. Cell Death Differ. 16(3):395-405(2009)
Dejosez, M., et al. Cell 133(7):1162-1174(2008)
Roussigne, M., et al. Trends Biochem. Sci. 28(2):66-69(2003)
Ueki, N., et al. Nat. Biotechnol. 16(13):1338-1342(1998)
Li, S.H., et al. Genomics 16(3):572-579(1993)