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Mouse Bmi1 Antibody

Mouse Monoclonal Antibody (Mab)

     
  • 1 - Mouse Bmi1 Antibody AM1980b
    Mouse Bmi1 antibody (Cat. #AM1980b) western blot analysis in mouse cerebellum tissue lysates (35μg/lane).This demonstrates the Mouse Bmi1 antibody detected the Mouse Bmi1 protein (arrow).
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, E
Primary Accession P25916
Other Accession NP_031578.2
Reactivity Mouse
Host Mouse
Clonality Monoclonal
Isotype IgG2b
Clone Names 353CT22.4.4
Additional info
Gene ID 12151
Other Names Polycomb complex protein BMI-1, Polycomb group RING finger protein 4, Bmi1, Bmi-1, Pcgf4
Target/Specificity This Mouse Bmi1 antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 136-163 amino acids from mouse Bmi1.
Dilution WB~~1:200~1600
Format Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Euglobin precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMouse Bmi1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Bmi1
Synonyms Bmi-1, Pcgf4
Function Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. In the PRC1 complex, it is required to stimulate the E3 ubiquitin-protein ligase activity of RNF2/RING2 (By similarity).
Cellular Location Nucleus. Cytoplasm.
Tissue Location Detected in most organs with high expression levels in thymus, heart, brain and testis
Research Areas

BACKGROUND

Component of the Polycomb group (PcG) multiprotein PRC1 complex, a complex required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (By similarity). In the PRC1 complex, it is required to stimulate the E3 ubiquitin-protein ligase activity of RNF2/RING2.

REFERENCES

Pereira, J.D., et al. Proc. Natl. Acad. Sci. U.S.A. 107(36):15957-15962(2010)
Chiba, T., et al. Hepatology 52(3):1111-1123(2010)
Maertens, G.N., et al. EMBO J. 29(15):2553-2565(2010)
Lee, K.S., et al. Oncogene 29(23):3349-3361(2010)
Schaller, M.A., et al. PLoS ONE 5 (8), E12172 (2010) :

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