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FSHB/FSH Antibody (Center)

Mouse Monoclonal Antibody (Mab)

     
  • 1 - FSHB/FSH Antibody (Center) AM1973b
    Western blot analysis of FSHB/FSH (arrow) using mouse polyclonal FSHB/FSH antibody (Center) (Cat. #AM1973b). 293 cell lysates (2 μg/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the FSHB/FSH gene.
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, E
Primary Accession P01225
Other Accession NP_000501.1, NP_001018090.1
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype IgG3
Clone Names 365CT24.1.1
Calculated MW 14700 Da
Additional info
Gene ID 2488
Other Names Follitropin subunit beta, Follicle-stimulating hormone beta subunit, FSH-B, FSH-beta, Follitropin beta chain, FSHB
Target/Specificity This FSHB/FSH antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 36-64 amino acids from the Central region of human FSHB/FSH.
Dilution WB~~1:150~1500
Format Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsFSHB/FSH Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name FSHB
Function Stimulates development of follicle and spermatogenesis in the reproductive organs.
Cellular Location Secreted.
Research Areas

BACKGROUND

The pituitary glycoprotein hormone family includes follicle-stimulating hormone, luteinizing hormone, chorionic gonadotropin, and thyroid-stimulating hormone. All of these glycoproteins consist of an identical alpha subunit and a hormone-specific beta subunit. This gene encodes the beta subunit of follicle-stimulating hormone. In conjunction with luteinizing hormone, follicle-stimulating hormone induces egg and sperm production. Alternative splicing results in two transcript variants encoding the same protein.

REFERENCES

Canzian, F., et al. Hum. Mol. Genet. 19(19):3873-3884(2010)
Corpuz, P.S., et al. Mol. Endocrinol. 24(5):1037-1051(2010)
Grigorova, M., et al. J. Clin. Endocrinol. Metab. 95(1):100-108(2010)
Ahn, J., et al. Hum. Mol. Genet. 18(19):3749-3757(2009)
Chakrabarti, B., et al. Autism Res 2(3):157-177(2009)

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