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STC2 Antibody

Mouse Monoclonal Antibody (Mab)

     
  • 1 - STC2  Antibody AM1955b
    STC2 Antibody (Cat. #AM1955b) western blot analysis in HepG2 cell line lysates (35μg/lane).This demonstrates the STC2 antibody detected the STC2 protein (arrow).
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, E
Primary Accession O76061
Other Accession NP_003705.1
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype IgA,k
Clone Names 339CT13.2.6
Calculated MW 33249 Da
Additional info
Gene ID 8614
Other Names Stanniocalcin-2, STC-2, Stanniocalcin-related protein, STC-related protein, STCRP, STC2
Target/Specificity This STC2 monoclonal antibody is generated from mouse immunized with STC2 recombinant protein.
Dilution WB~~1:100~250
Format Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsSTC2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name STC2
Function Has an anti-hypocalcemic action on calcium and phosphate homeostasis.
Cellular Location Secreted.
Tissue Location Expressed in a variety of tissues including muscle, heart, pancreas, kidney, spleen, prostate, small intestine, colon and peripheral blood leukocytes
Research Areas

BACKGROUND

This gene encodes a secreted, homodimeric glycoprotein that is expressed in a wide variety of tissues and may have autocrine or paracrine functions. The encoded protein has 10 of its 15 cysteine residues conserved among stanniocalcin family members and is phosphorylated by casein kinase 2 exclusively on its serine residues. Its C-terminus contains a cluster of histidine residues which may interact with metal ions. The protein may play a role in the regulation of renal and intestinal calcium and phosphate transport, cell metabolism, or cellular calcium/phosphate homeostasis. Constitutive overexpression of human stanniocalcin 2 in mice resulted in pre- and postnatal growth restriction, reduced bone and skeletal muscle growth, and organomegaly. Expression of this gene is induced by estrogen and altered in some breast cancers.

REFERENCES

Yokoyama, K., et al. Nephron Clin Pract 115 (4), C237-C243 (2010) :
Law, A.Y., et al. Exp. Cell Res. 316(3):466-476(2010)
Volland, S., et al. Int. J. Cancer 125(9):2049-2057(2009)
Ieta, K., et al. Int. J. Cancer 125(4):926-931(2009)
Tamura, K., et al. Cancer Sci. 100(5):914-919(2009)

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