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LGALS3 Antibody (C-term)

Mouse Monoclonal Antibody (Mab)

     
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  • 1 - LGALS3 Antibody (C-term) AM1951b
    LGALS3 Antibody (C-term) (Cat. #AM1951b) western blot analysis in NCI-H460 cell line lysates (35μg/lane).This demonstrates the LGALS3 antibody detected the LGALS3 protein (arrow).
  • 14 - LGALS3 Antibody (C-term) AM1951b
    LGALS3 Antibody (C-term) (Cat. #AM1951b)immunohistochemistry analysis in formalin fixed and paraffin embedded human breast carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of LGALS3 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
  • 14 - LGALS3 Antibody (C-term) AM1951b
    LGALS3 Antibody (C-term) (Cat. #AM1951b)immunohistochemistry analysis in formalin fixed and paraffin embedded human colon carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of LGALS3 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, IHC-P, E
Primary Accession P17931
Other Accession NP_002297.2
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype IgG1,k
Clone Names 320CT4.5.2
Calculated MW 26152 Da
Additional info
Gene ID 3958
Other Names Galectin-3, Gal-3, 35 kDa lectin, Carbohydrate-binding protein 35, CBP 35, Galactose-specific lectin 3, Galactoside-binding protein, GALBP, IgE-binding protein, L-31, Laminin-binding protein, Lectin L-29, Mac-2 antigen, LGALS3, MAC2
Target/Specificity This LGALS3 antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 163-191 amino acids from the C-terminal region of human LGALS3.
Dilution WB~~1:100~500
IHC-P~~1:10~50
Format Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsLGALS3 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name LGALS3
Synonyms MAC2
Function Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis (By similarity). In the nucleus: acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells. Together with TRIM16, coordinates the recognition of membrane damage with mobilization of the core autophagy regulators ATG16L1 and BECN1 in response to damaged endomembranes.
Cellular Location Cytoplasm. Nucleus. Secreted. Note=Secreted by a non-classical secretory pathway and associates with the cell surface
Tissue Location A major expression is found in the colonic epithelium. It is also abundant in the activated macrophages Expressed in fetal membranes.
Research Areas

BACKGROUND

This gene encodes a member of the galectin family of carbohydrate binding proteins. Members of this protein family have an affinity for beta-galactosides. The encoded protein is characterized by an N-terminal proline-rich tandem repeat domain and a single C-terminal carbohydrate recognition domain. This protein can self-associate through the N-terminal domain allowing it to bind to multivalent saccharide ligands. This protein localizes to the extracellular matrix, the cytoplasm and the nucleus. This protein plays a role in numerous cellular functions including apoptosis, innate immunity, cell adhesion and T-cell regulation. Alternate splicing results in multiple transcript variants.

REFERENCES

Salomonsson, E., et al. J. Biol. Chem. 285(45):35079-35091(2010)
Debierre-Grockiego, F., et al. J. Biol. Chem. 285(43):32744-32750(2010)
Zhou, J.Y., et al. J. Proteome Res. 9(10):5133-5141(2010)
Markowska, A.I., et al. J. Exp. Med. 207(9):1981-1993(2010)
Mazurek, N., et al. J. Biol. Chem. 275(46):36311-36315(2000)

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