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>   首页   >   产品   >   一抗   >   癌症   >   CD79A Antibody (C-term)   

CD79A Antibody (C-term)

Mouse Monoclonal Antibody (Mab)

     
  • 1 - CD79A Antibody (C-term) AM1946b
    CD79A Antibody (C-term) (Cat. #AM1946b) western blot analysis in mouse spleen tissue lysates (35μg/lane).This demonstrates the CD79A antibody detected the CD79A protein (arrow).
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, E
Primary Accession P11912
Other Accession NP_001774.1
Reactivity Mouse
Host Mouse
Clonality Monoclonal
Isotype IgG1,k
Clone Names 299CT22.1.2
Calculated MW 25038 Da
Additional info
Gene ID 973
Other Names B-cell antigen receptor complex-associated protein alpha chain, Ig-alpha, MB-1 membrane glycoprotein, Membrane-bound immunoglobulin-associated protein, Surface IgM-associated protein, CD79a, CD79A, IGA, MB1
Target/Specificity This CD79A antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 160-188 amino acids from the C-terminal region of human CD79A.
Dilution WB~~1:100~250
Format Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCD79A Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CD79A
Synonyms IGA, MB1
Function Required in cooperation with CD79B for initiation of the signal transduction cascade activated by binding of antigen to the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Also required for BCR surface expression and for efficient differentiation of pro- and pre-B-cells. Stimulates SYK autophosphorylation and activation. Binds to BLNK, bringing BLNK into proximity with SYK and allowing SYK to phosphorylate BLNK. Also interacts with and increases activity of some Src- family tyrosine kinases. Represses BCR signaling during development of immature B-cells.
Cellular Location Cell membrane; Single-pass type I membrane protein. Note=Following antigen binding, the BCR has been shown to translocate from detergent-soluble regions of the cell membrane to lipid rafts although signal transduction through the complex can also occur outside lipid rafts.
Tissue Location B-cells.
Research Areas

BACKGROUND

The B lymphocyte antigen receptor is a multimeric complex that includes the antigen-specific component, surface immunoglobulin (Ig). Surface Ig non-covalently associates with two other proteins, Ig-alpha and Ig-beta, which are necessary for expression and function of the B-cell antigen receptor. This gene encodes the Ig-alpha protein of the B-cell antigen component. Alternatively spliced transcript variants encoding different isoforms have been described.

REFERENCES

Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Davila, S., et al. Genes Immun. 11(3):232-238(2010)
Hoeller, S., et al. Histopathology 56(2):217-228(2010)
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
Tanaka, T., et al. Pathol. Int. 59(11):804-808(2009)

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