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TLR3 Antibody

Mouse Monoclonal Antibody (Mab)

     
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  • 1 - TLR3 Antibody AM1944b
    Anti-TLR3 Antibody at 1:500 dilution + K562 whole cell lysates Lysates/proteins at 20 μg per lane. Secondary Goat Anti-mouse IgG, (H+L), Peroxidase conjugated at 1/10000 dilution Predicted band size : 104 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
  • 1 - TLR3 Antibody AM1944b
    TLR3 Antibody (Cat. #AM1944b) western blot analysis in mouse heart tissue lysates (35μg/lane).This demonstrates the TLR3 antibody detected the TLR3 protein (arrow).
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, E
Primary Accession O15455
Other Accession NP_003256.1
Reactivity Human, Mouse
Host Mouse
Clonality Monoclonal
Isotype IgM,k
Clone Names 303CT19.9.2
Additional info
Gene ID 7098
Other Names Toll-like receptor 3, CD283, TLR3
Target/Specificity This TLR3 monoclonal antibody is generated from mouse immunized with TLR3 recombinant protein.
Dilution WB~~1:100
Format Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Euglobin precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsTLR3 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TLR3
Function Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR3 is a nucleotide-sensing TLR which is activated by double-stranded RNA, a sign of viral infection. Acts via the adapter TRIF/TICAM1, leading to NF-kappa-B activation, IRF3 nuclear translocation, cytokine secretion and the inflammatory response.
Cellular Location Endoplasmic reticulum membrane; Single-pass type I membrane protein. Endosome membrane
Tissue Location Expressed at high level in placenta and pancreas. Also detected in CD11c+ immature dendritic cells. Only expressed in dendritic cells and not in other leukocytes, including monocyte precursors. TLR3 is the TLR that is expressed most strongly in the brain, especially in astrocytes, glia, and neurons.
Research Areas

BACKGROUND

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor is most abundantly expressed in placenta and pancreas, and is restricted to the dendritic subpopulation of the leukocytes. It recognizes dsRNA associated with viral infection, and induces the activation of NF-kappaB and the production of type I interferons. It may thus play a role in host defense against viruses. Use of alternative polyadenylation sites to generate different length transcripts has been noted for this gene.

REFERENCES

Romero, R., et al. Am. J. Obstet. Gynecol. 203 (4), 361 (2010) :
Perez de Diego, R., et al. Immunity 33(3):400-411(2010)
Zhou, Y., et al. Immunology 131(1):40-49(2010)
Perrot, I., et al. J. Immunol. 185(4):2080-2088(2010)
Paone, A., et al. Neoplasia 12(7):539-549(2010)

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