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ATG4C Antibody

Mouse Monoclonal Antibody (Mab)

     
  • 1 - ATG4C Antibody AM1933b
    ATG4C Antibody (Cat. #AM1933b) western blot analysis in mouse heart tissue lysates (35μg/lane).This demonstrates the ATG4C antibody detected the ATG4C protein (arrow).
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, E
Primary Accession Q96DT6
Other Accession NP_116241.2, NP_835739.1
Reactivity Mouse
Host Mouse
Clonality Monoclonal
Isotype IgG1,k
Clone Names 287CT12.2.2
Calculated MW 52497 Da
Additional info
Gene ID 84938
Other Names Cysteine protease ATG4C, 3422-, AUT-like 3 cysteine endopeptidase, Autophagin-3, Autophagy-related cysteine endopeptidase 3, Autophagy-related protein 4 homolog C, ATG4C, APG4C, AUTL1, AUTL3
Target/Specificity This ATG4C monoclonal antibody is generated from mouse immunized with ATG4C recombinant protein.
Dilution WB~~1:100
Format Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsATG4C Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ATG4C
Synonyms APG4C, AUTL1, AUTL3
Function Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Is not essential for autophagy development under normal conditions but is required for a proper autophagic response under stressful conditions such as prolonged starvation (By similarity). Cleaves the C-terminal amino acid of ATG8 family proteins MAP1LC3 and GABARAPL2, to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Has also an activity of delipidating enzyme for the PE-conjugated forms.
Cellular Location Cytoplasm.
Tissue Location Highly expressed in skeletal muscle, heart, liver and testis.
Research Areas

BACKGROUND

Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene encodes a member of the autophagin protein family. The encoded protein is also designated as a member of the C-54 family of cysteine proteases. Alternate transcriptional splice variants, encoding the same protein, have been characterized. [provided by RefSeq].

REFERENCES

Kathiresan, S., et al. Nat. Genet. 40(2):189-197(2008)
Marino, G., et al. J. Biol. Chem. 282(25):18573-18583(2007)
Levy, D., et al. BMC Med. Genet. 8 SUPPL 1, S3 (2007) :
Marino, G., et al. J. Biol. Chem. 278(6):3671-3678(2003)

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