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>   首页   >   产品   >   一抗   >   癌症   >   DESM Antibody   

DESM Antibody

Mouse Monoclonal Antibody (Mab)

     
  • 1 - DESM Antibody AM1926b
    DESM Antibody (Cat. #AM1926b) western blot analysis in CEM cell line lysates (35μg/lane).This demonstrates the DESM antibody detected the DESM protein (arrow).
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, E
Primary Accession P17661
Other Accession NP_001918.3
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype IgM,k
Clone Names 290CT7.1.1
Calculated MW 53536 Da
Additional info
Gene ID 1674
Other Names Desmin, DES
Target/Specificity This DESM monoclonal antibody is generated from mouse immunized with DESM recombinant protein.
Dilution WB~~1:100~250
Format Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Euglobin precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsDESM Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name DES
Function Desmin are class-III intermediate filaments found in muscle cells. In adult striated muscle they form a fibrous network connecting myofibrils to each other and to the plasma membrane from the periphery of the Z-line structures.
Cellular Location Cytoplasm.
Research Areas

BACKGROUND

This gene encodes a muscle-specific class III intermediate filament. Homopolymers of this protein form a stable intracytoplasmic filamentous network connecting myofibrils to each other and to the plasma membrane. Mutations in this gene are associated with desmin-related myopathy, a familial cardiac and skeletal myopathy (CSM), and with distal myopathies. [provided by RefSeq].

REFERENCES

Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
van Spaendonck-Zwarts, K., et al. Clin. Genet. (2010) In press :
Zimmerman, R.S., et al. Genet. Med. 12(5):268-278(2010)
Bar, H., et al. J. Mol. Biol. 397(5):1188-1198(2010)
Levin, J., et al. J. Neuropathol. Exp. Neurol. 69(4):415-424(2010)

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