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TGFB2 Antibody

Mouse Monoclonal Antibody (Mab)

     
  • 1 - TGFB2 Antibody AM1893B
    All lanes : Anti- at 1:500-1:1000 dilution Lane 1: 293 whole cell lysate Lane 2: K562 whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-mouse IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 48 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
  • 14 - TGFB2 Antibody AM1893B
    TGFB2 Antibody (Cat. #AM1893b)immunohistochemistry analysis in formalin fixed and paraffin embedded human breast carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of TGFB2 Antibody for immunohistochemistry. Clinical relevance has not been evaluated.
  • 14 - TGFB2 Antibody AM1893B
    TGFB2 Antibody (Cat. #AM1893b)immunohistochemistry analysis in formalin fixed and paraffin embedded human colon carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of TGFB2 Antibody for immunohistochemistry. Clinical relevance has not been evaluated.
  • 3 - TGFB2 Antibody AM1893B
    Confocal immunofluorescent analysis of TGFB2 Antibody (Cat#AM1893b) with A549 cell followed by Alexa Fluor® 488-conjugated goat anti-mouse lgG (green).DAPI was used to stain the cell nuclear (blue).
  • 1 - TGFB2 Antibody AM1893B
    TGFB2/MB10181 antibody (Cat. #AM1893b) western blot analysis in A549 cell line lysates (35μg/lane).This demonstrates the TGFB2/MB10181 antibody detected the TGFB2/MB10181 protein (arrow).
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, IHC-P, IF, E
Primary Accession P61812
Other Accession NP_001129071.1, NP_003229.1
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype IgG1,K
Clone Names 220ct16.4.3.1
Calculated MW 47748 Da
Additional info
Gene ID 7042
Other Names Transforming growth factor beta-2, TGF-beta-2, BSC-1 cell growth inhibitor, Cetermin, Glioblastoma-derived T-cell suppressor factor, G-TSF, Polyergin, Latency-associated peptide, LAP, TGFB2
Target/Specificity This TGFB2 monoclonal antibody is generated from mouse immunized with TGFB2 recombinant protein.
Dilution WB~~1:100~1000
IHC-P~~1:10~50
IF~~1:10~50
Format Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsTGFB2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TGFB2
Function TGF-beta 2 has suppressive effects on interleukin-2 dependent T-cell growth.
Cellular Location Secreted.
Research Areas

BACKGROUND

This gene encodes a member of the transforming growth factor beta (TGFB) family of cytokines, which are multifunctional peptides that regulate proliferation, differentiation, adhesion, migration, and other functions in many cell types by transducing their signal through combinations of transmembrane type I and type II receptors (TGFBR1 and TGFBR2) and their downstream effectors, the SMAD proteins. Disruption of the TGFB/SMAD pathway has been implicated in a variety of human cancers. The encoded protein is secreted and has suppressive effects of interleukin-2 dependent T-cell growth. Translocation t(1;7)(q41;p21) between this gene and HDAC9 is associated with Peters' anomaly, a congenital defect of the anterior chamber of the eye. The knockout mice lacking this gene show perinatal mortality and a wide range of developmental, including cardiac, defects. Alternatively spliced transcript variants encoding different isoforms have been identified.

REFERENCES

Nalpas, B., et al. Gut 59(8):1120-1126(2010)
Bailey, S.D., et al. Diabetes Care (2010) In press :
Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) :
Johnatty, S.E., et al. PLoS Genet. 6 (7), E1001016 (2010) :
Sambo, M.R., et al. PLoS ONE 5 (6), E11141 (2010) :

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