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TGFB2 antibody (Ascites)

Mouse Monoclonal Antibody (Mab)

     
  • 1 - TGFB2 antibody  (Ascites) AM1893a
    All lanes : Anti-TGFB2 antibody at 1:1000 dilution Lane 1: MCF-7 whole cell lysate Lane 2: HUVEC whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-mouse IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 48 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
  • 1 - TGFB2 antibody  (Ascites) AM1893a
    TGFB2 antibody (Cat. #AM1893a) western blot analysis in A549 cell line lysates (35μg/lane).This demonstrates the TGFB2 antibody detected the TGFB2 protein (arrow).
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, E
Primary Accession P61812
Other Accession NP_001129071.1, NP_003229.1
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype IgG1,K
Clone Names 220ct16.4.3.1
Calculated MW 47748 Da
Additional info
Gene ID 7042
Other Names Transforming growth factor beta-2, TGF-beta-2, BSC-1 cell growth inhibitor, Cetermin, Glioblastoma-derived T-cell suppressor factor, G-TSF, Polyergin, Latency-associated peptide, LAP, TGFB2
Target/Specificity This TGFB2 monoclonal antibody is generated from mouse immunized with TGFB2 recombinant protein.
Dilution WB~~1:500~16000
Format Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsTGFB2 antibody (Ascites) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TGFB2
Function Transforming growth factor beta-2 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains, which constitute the regulatory and active subunit of TGF-beta-2, respectively.
Cellular Location Latency-associated peptide: Secreted, extracellular space, extracellular matrix {ECO:0000250|UniProtKB:P01137}
Research Areas

BACKGROUND

This gene encodes a member of the transforming growth factor beta (TGFB) family of cytokines, which are multifunctional peptides that regulate proliferation, differentiation, adhesion, migration, and other functions in many cell types by transducing their signal through combinations of transmembrane type I and type II receptors (TGFBR1 and TGFBR2) and their downstream effectors, the SMAD proteins. Disruption of the TGFB/SMAD pathway has been implicated in a variety of human cancers. The encoded protein is secreted and has suppressive effects of interleukin-2 dependent T-cell growth. Translocation t(1;7)(q41;p21) between this gene and HDAC9 is associated with Peters' anomaly, a congenital defect of the anterior chamber of the eye. The knockout mice lacking this gene show perinatal mortality and a wide range of developmental, including cardiac, defects. Alternatively spliced transcript variants encoding different isoforms have been identified.

REFERENCES

Nalpas, B., et al. Gut 59(8):1120-1126(2010)
Bailey, S.D., et al. Diabetes Care (2010) In press :
Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) :
Johnatty, S.E., et al. PLoS Genet. 6 (7), E1001016 (2010) :
Sambo, M.R., et al. PLoS ONE 5 (6), E11141 (2010) :

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