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PAX6 Antibody (Ascites)

Mouse Monoclonal Antibody (Mab)

     
  • 1 - PAX6 Antibody (Ascites) AM1871a
    PAX6 (Cat. #AM1871a) western blot analysis in 293 cell line lysates (35μg/lane).This demonstrates the PAX6 antibody detected the PAX6 protein (arrow).
  • 3 - PAX6 Antibody (Ascites) AM1871a
    Confocal immunofluorescent analysis of PAX6 Antibody (Ascites)(Cat#AM1871a) with Hela cell followed by Alexa Fluor® 488-conjugated goat anti-mouse lgG (green). Actin filaments have been labeled with Alexa Fluor® 555 phalloidin (red).DAPI was used to stain the cell nuclear (blue).
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, IF, E
Primary Accession P26367
Other Accession P63015, Q1LZF1, NP_000271.1, NP_001595.2
Reactivity Human
Predicted Bovine, Mouse
Host Mouse
Clonality Monoclonal
Isotype IgM,K
Clone Names 193CT15.2.2
Calculated MW 46683 Da
Additional info
Gene ID 5080
Other Names Paired box protein Pax-6, Aniridia type II protein, Oculorhombin, PAX6, AN2
Target/Specificity This PAX6 Monoclonal antibody was raised using purified His-tagged recombinant human PAX6.
Dilution WB~~1:500~16000
IF~~1:10~50
Format Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsPAX6 Antibody (Ascites) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PAX6
Synonyms AN2
Function Transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas. Required for the differentiation of pancreatic islet alpha cells (By similarity). Competes with PAX4 in binding to a common element in the glucagon, insulin and somatostatin promoters. Regulates specification of the ventral neuron subtypes by establishing the correct progenitor domains (By similarity). Isoform 5a appears to function as a molecular switch that specifies target genes.
Cellular Location Nucleus.
Tissue Location Fetal eye, brain, spinal cord and olfactory epithelium. Isoform 5a is less abundant than the PAX6 shorter form
Research Areas

BACKGROUND

This gene encodes paired box gene 6, one of many human homologs of the Drosophila melanogaster gene prd. In addition to the hallmark feature of this gene family, a conserved paired box domain, the encoded protein also contains a homeo box domain. Both domains are known to bind DNA, and function as regulators of gene transcription. This gene is expressed in the developing nervous system, and in developing eyes. Mutations in this gene are known to cause ocular disorders such as aniridia and Peter's anomaly. Alternatively spliced transcript variants encoding either the same or different isoform have been found for this gene. [provided by RefSeq].

REFERENCES

Gosmain, Y., et al. J. Biol. Chem. 285(43):33381-33393(2010)
Vuzman, D., et al. Biophys. J. 99(4):1202-1211(2010)
Zhang, X., et al. Cell Stem Cell 7(1):90-100(2010)
Bremond-Gignac, D., et al. Mol. Vis. 16, 1705-1711 (2010) :
Cai, F., et al. Mol. Vis. 16, 1141-1145 (2010) :

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