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|Application ||WB, IHC-P, IF, E|
|Calculated MW||49880 Da|
|Other Names||Glial fibrillary acidic protein, GFAP, GFAP|
|Target/Specificity||This GFAP monoclonal antibody is generated from mouse immunized with GFAP recombinant protein.|
|Format||Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||GFAP Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||GFAP, a class-III intermediate filament, is a cell- specific marker that, during the development of the central nervous system, distinguishes astrocytes from other glial cells.|
|Cellular Location||Cytoplasm. Note=Associated with intermediate filaments|
|Tissue Location||Expressed in cells lacking fibronectin.|
Author : Bajpai VK1,Kerosuo L2,Tseropoulos G1,Cummings KA3,Wang X1,Lei P1,Liu B4,5,Liu S4,5,Popescu GK3,Bronner ME2,Andreadis ST1,6,7.
Stem Cells. 2017 May;35(5):1402-1415. doi: 10.1002/stem.2583. Epub 2017 Mar 5.
Provided below are standard protocols that you may find useful for product applications.
This gene encodes one of the major intermediate filament proteins of mature astrocytes. It is used as a marker to distinguish astrocytes from other glial cells during development. Mutations in this gene cause Alexander disease, a rare disorder of astrocytes in the central nervous system. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
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