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TNK1 Antibody

Mouse Monoclonal Antibody (Mab)

     
  • 1 - TNK1 Antibody AM1861b
    TNK1 Antibody (Cat. #AM1861b) western blot analysis in mouse brain tissue lysates (35μg/lane).This demonstrates the TNK1 antibody detected the TNK1 protein (arrow).
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, E
Primary Accession Q13470
Other Accession NP_003976.2
Reactivity Mouse
Host Mouse
Clonality Monoclonal
Isotype IgG1,K
Clone Names 170CT7.5.4
Calculated MW 72468 Da
Additional info
Gene ID 8711
Other Names Non-receptor tyrosine-protein kinase TNK1, CD38 negative kinase 1, TNK1 {ECO:0000312|EMBL:AAC994121}
Target/Specificity This TNK1 monoclonal antibody is generated from mouse immunized with TNK1 recombinant protein.
Dilution WB~~1:100~1000
Format Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsTNK1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TNK1 {ECO:0000312|EMBL:AAC99412.1}
Function Involved in negative regulation of cell growth. Has tumor suppressor properties. Plays a negative regulatory role in the Ras-MAPK pathway. May function in signaling pathways utilized broadly during fetal development and more selectively in adult tissues and in cells of the lymphohematopoietic system. Could specifically be involved in phospholipid signal transduction.
Cellular Location Cytoplasm. Membrane; Peripheral membrane protein
Tissue Location Expressed in all umbilical cord blood, bone marrow and adult blood cell sub-populations and in several leukemia cell lines. Highly expressed in fetal blood, brain, lung, liver and kidney. Detected at lower levels in adult prostate, testis, ovary, small intestine and colon. Not expressed in adult lung, liver, kidney or brain.
Research Areas

BACKGROUND

Involved in negative regulation of cell growth. Has tumor suppressor properties. Plays a negative regulatory role in the Ras-MAPK pathway. May function in signaling pathways utilized broadly during fetal development and more selectively in adult tissues and in cells of the lymphohematopoietic system. Could specifically be involved in phospholipid signal transduction.

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