EIF4E Antibody
Mouse Monoclonal Antibody (Mab)
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- 文献引用 : 1
- 实验流程
- 背景知识
Application ![]()
| WB, IF, E |
---|---|
Primary Accession | P06730 |
Other Accession | NP_001959.1 |
Reactivity | Human, Mouse |
Host | Mouse |
Clonality | Monoclonal |
Isotype | IgG1,K |
Clone Names | 163CT48.1.9 |
Calculated MW | 25097 Da |
Gene ID | 1977 |
---|---|
Other Names | Eukaryotic translation initiation factor 4E, eIF-4E, eIF4E, eIF-4F 25 kDa subunit, mRNA cap-binding protein, EIF4E, EIF4EL1, EIF4F |
Target/Specificity | This EIF4E monoclonal antibody is generated from mouse immunized with EIF4E recombinant protein. |
Dilution | WB~~1:2000 IF~~1:10~50 |
Format | Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | EIF4E Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | EIF4E |
---|---|
Synonyms | EIF4EL1, EIF4F |
Function | Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit mediates the binding to the mRNA cap. |
Cellular Location | Cytoplasm, P-body. Cytoplasm |
Research Areas
Author : Hoeffer CA1, Santini E, Ma T, Arnold EC, Whelan AM, Wong H, Pierre P, Pelletier J, Klann E. J Neurophysiol. 2013 Jan;109(1):68-76. doi: 10.1152/jn.00342.2012. Epub 2012 Oct 10. |
23054596 |
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
EIF4E recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures.

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