癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
EIF4E Antibody
Mouse Monoclonal Antibody (Mab)
- 产品详情
- 文献引用 : 1
- 实验流程
- 背景知识
Application 
| IF, WB, E |
|---|---|
| Primary Accession | P06730 |
| Other Accession | NP_001959.1 |
| Reactivity | Human, Mouse |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG1,K |
| Clone Names | 163CT48.1.9 |
| Calculated MW | 25097 Da |
| Gene ID | 1977 |
|---|---|
| Other Names | Eukaryotic translation initiation factor 4E, eIF-4E, eIF4E, eIF-4F 25 kDa subunit, mRNA cap-binding protein, EIF4E, EIF4EL1, EIF4F |
| Target/Specificity | This EIF4E monoclonal antibody is generated from mouse immunized with EIF4E recombinant protein. |
| Dilution | WB~~1:2000 IF~~1:10~50 |
| Format | Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | EIF4E Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | EIF4E |
|---|---|
| Synonyms | EIF4EL1, EIF4F |
| Function | Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit mediates the binding to the mRNA cap. |
| Cellular Location | Cytoplasm, P-body. Cytoplasm |
Research Areas
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Author : Hoeffer CA1, Santini E, Ma T, Arnold EC, Whelan AM, Wong H, Pierre P, Pelletier J, Klann E. J Neurophysiol. 2013 Jan;109(1):68-76. doi: 10.1152/jn.00342.2012. Epub 2012 Oct 10. |
23054596 |
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
EIF4E recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures.
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