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ALDH2 Antibody

Purified Mouse Monoclonal Antibody (Mab)

     
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  • 1 - ALDH2 Antibody AM1831a
    Western blot analysis of lysates from NCI-H292, A549, HepG2 cell line (from left to right), using ALDH2 Antibody(Cat. #AM1831a). AM1831a was diluted at 1:1000 at each lane. A goat anti-mouse IgG H&L(HRP) at 1:3000 dilution was used as the secondary antibody. Lysates at 35μg per lane.
  • 14 - ALDH2 Antibody AM1831a
    ALDH2 Monoclonal Antibody (Cat. #AM1831a) immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the ALDH2 Monoclonal Antibody for immunohistochemistry. Clinical relevance has not been evaluated.
  • 4 - ALDH2 Antibody AM1831a
    ALDH2 Monoclonal Antibody (Cat. #AM1831a) flow cytometric analysis of HepG2 cells (right histogram) compared to a negative control cell (left histogram).PE-conjugated goat-anti-mouse secondary antibodies were used for the analysis.
  • 3 - ALDH2 Antibody AM1831a
    Confocal immunofluorescent analysis of ALDH2 Antibody (Cat#AM1831a) with HepG2 cell followed by Alexa Fluor® 488-conjugated goat anti-mouse lgG (green). DAPI was used to stain the cell nuclear (blue).
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
IHC-P, FC, IF, WB, E
Primary Accession P05091
Other Accession NP_000681
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype IgG1,Ig?
Clone Names 138CT22.3.8
Calculated MW 56381 Da
Additional info
Gene ID 217
Other Names Aldehyde dehydrogenase, mitochondrial, ALDH class 2, ALDH-E2, ALDHI, ALDH2, ALDM
Target/Specificity This ALDH2 Monoclonal antibody is generated from mouse immunized with ALDH2 recombinant protein.
Dilution WB~~1:1000
IHC-P~~1:50~100
FC~~1:10~50
IF~~1:10~50
Format Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsALDH2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ALDH2
Synonyms ALDM
Cellular Location Mitochondrion matrix.
Research Areas
UBE2C Is a Potential Biomarker of Intestinal-Type Gastric Cancer With Chromosomal Instability.
Author : Zhang J1,Liu X1,Yu G2,3,Liu L1,Wang J2,Chen X4,Bian Y4,Ji Y5,Zhou X6,Chen Y1,Ji J1,Xiang Z1,Guo L1,Fang J4,Sun Y5,Cao H4,Zhu Z1,Yu Y1.
Front Pharmacol. 2018 Aug 2;9:847. doi: 10.3389/fphar.2018.00847. eCollection 2018.
30116193

BACKGROUND

This protein belongs to the aldehyde dehydrogenase family of proteins. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. Two major liver isoforms of this enzyme, cytosolic and mitochondrial, can be distinguished by their electrophoretic mobilities, kinetic properties, and subcellular localizations. Most Caucasians have two major isozymes, while approximately 50% of Orientals have only the cytosolic isozyme, missing the mitochondrial isozyme. A remarkably higher frequency of acute alcohol intoxication among Orientals than among Caucasians could be related to the absence of the mitochondrial isozyme. This gene encodes a mitochondrial isoform, which has a low Km for acetaldehydes, and is localized in mitochondrial matrix.

REFERENCES

Relationship between genetic polymorphisms of ALDH2 and ADH1B and esophageal cancer risk: a meta-analysis. Yang SJ, et al. World J Gastroenterol, 2010 Sep 7. PMID 20806441. Effects of alcohol-drinking behaviour and ADH1B and ALDH2 polymorphisms on basal DNA damage in human mononuclear cells as determined by the comet assay. Weng H, et al. Mutat Res, 2010 Aug 30. PMID 20685249. Evaluation of a brief web-based genetic feedback intervention for reducing alcohol-related health risks associated with ALDH2. Hendershot CS, et al. Ann Behav Med, 2010 Aug. PMID 20652463. Association of genetic polymorphisms of aldehyde dehydrogenase-2 with esophageal squamous cell dysplasia. Zhou YZ, et al. World J Gastroenterol, 2010 Jul 21. PMID 20632450. Variation at the NFATC2 Locus Increases the Risk of Thiazolinedinedione-Induced Edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) Study. Bailey SD, et al. Diabetes Care, 2010 Jul 13. PMID 20628086.

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