|Application ||WB, E|
|Calculated MW||46557 Da|
|Other Names||Serpin A9, Centerin, Germinal center B-cell-expressed transcript 1 protein, SERPINA9, GCET1, SERPINA11|
|Target/Specificity||This SPA9 antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 158-186 amino acids from the N-terminal region of human SPA9.|
|Format||Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SPA9 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Protease inhibitor that inhibits trypsin and trypsin- like serine proteases (in vitro). Inhibits plasmin and thrombin with lower efficiency (in vitro).|
|Cellular Location||Isoform 1: Secreted. Isoform 3: Cytoplasm. Isoform 5: Cytoplasm. Isoform 7: Membrane; Single- pass type II membrane protein|
|Tissue Location||Highly expressed in normal germinal center (GC) B-cells and GC B-cell-derived malignancies|
Genome sequence of Shigella flexneri 2a: insights into pathogenicity through comparison with genomes of Escherichia coli K12 and O157. Jin Q, et al. Nucleic Acids Res, 2002 Oct 15. PMID 12384590.
The virulence plasmid pWR100 and the repertoire of proteins secreted by the type III secretion apparatus of Shigella flexneri. Buchrieser C, et al. Mol Microbiol, 2000 Nov. PMID 11115111.
Eight genes in region 5 that form an operon are essential for invasion of epithelial cells by Shigella flexneri 2a. Sasakawa C, et al. J Bacteriol, 1993 Apr. PMID 8385666.
Surface presentation of Shigella flexneri invasion plasmid antigens requires the products of the spa locus. Venkatesan MM, et al. J Bacteriol, 1992 Mar. PMID 1312536.