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CD34 Antibody (Center)

Purified Mouse Monoclonal Antibody (Mab)

     
  • 14 - CD34 Antibody (Center) AM1825a
    Formalin-fixed and paraffin-embedded human hepatocarcinoma with CD34 Monoclonal Antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
  • 1 - CD34 Antibody (Center) AM1825a
    Anti-CD34 Antibody (Center) at 1:1000 dilution + NIH/3T3 whole cell lysate Secondary Goat Anti-mouse IgG, (H+L),Peroxidase conjugated at 1/10000 dilution. Predicted band size : 40716 Da Blocking/Dilution buffer: 5% NFDM/TBST.
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  • 文献引用 : 4
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, IHC-P, E
Primary Accession P28906
Other Accession NP_001764
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype IgG1κ
Clone Names 132CT29.1.5
Additional info
Gene ID 947
Other Names Hematopoietic progenitor cell antigen CD34, CD34, CD34
Target/Specificity This CD34 antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 185-214 amino acids from the Central region of human CD34.
Dilution IHC-P~~1:50~100
WB~~1:1000
Format Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCD34 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CD34
Function Possible adhesion molecule with a role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. Could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. Presents carbohydrate ligands to selectins.
Cellular Location Membrane; Single-pass type I membrane protein
Tissue Location Selectively expressed on hematopoietic progenitor cells and the small vessel endothelium of a variety of tissues
Research Areas
Butaselen prevents hepatocarcinogenesis and progression through inhibiting thioredoxin reductase activity.
Author : Zheng X1,Ma W1,Sun R1,Yin H2,Lin F3,Liu Y1,Xu W4,Zeng H5.
Redox Biol. 2017 Sep 22;14:237-249. doi: 10.1016/j.redox.2017.09.014. [Epub ahead of print]
28965082
Overexpression of FZD1 and CAIX are Associated with Invasion, Metastasis, and Poor-Prognosis of the Pancreatic Ductal Adenocarcinoma.
Author : Yang L1,Yang Z2,Li D3,Liu Z2,Zou Q4,Yuan Y4,Xu H5.
Pathol Oncol Res. 2017 Sep 18. doi: 10.1007/s12253-017-0284-5. [Epub ahead of print]
28921449
Concurrent chemoradiotherapy with low-dose docetaxel inhibits the growth of DU-145 prostate cancer xenografts.
Author : Wang L, Huang X, Zheng X, Wang X, Li S, Zhang L, Yang Z.
Clin Transl Oncol. 2013 Oct 9. [Epub ahead of print]
24105048
Inhibition of PDGF, TGF-β, and Abl signaling and reduction of liver fibrosis by the small molecule Bcr-Abl tyrosine kinase antagonist Nilotinib.
Author : Liu Y, Wang Z, Kwong SQ, Lui EL, Friedman SL, Li FR, Lam RW, Zhang GC, Zhang H, Ye T.
J Hepatol. 2011 Sep;55(3):612-25. doi: 10.1016/j.jhep.2010.11.035. Epub 2011 Jan 18.
21251937

BACKGROUND

CD34 is a monomeric cell surface antigen with a molecular mass of approximately 110 kD that is selectively expressed on human hematopoietic progenitor cells.

REFERENCES

Genome-wide association analysis identifies multiple loci related to resting heart rate. Eijgelsheim M, et al. Hum Mol Genet, 2010 Oct 1. PMID 20639392. The effect of CXCL12 processing on CD34+ cell migration in myeloproliferative neoplasms. Cho SY, et al. Cancer Res, 2010 Apr 15. PMID 20388788. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614. Junctional adhesion molecule A expressed on human CD34+ cells promotes adhesion on vascular wall and differentiation into endothelial progenitor cells. Stellos K, et al. Arterioscler Thromb Vasc Biol, 2010 Jun. PMID 20378847. Human gallbladder carcinoma: Role of neurotrophins, MIB-1, CD34 and CA15-3. Artico M, et al. Eur J Histochem, 2010 Mar 11. PMID 20353905.

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