|Application ||WB, E|
|Calculated MW||40403 Da|
|Other Names||PR domain zinc finger protein 12, 211-, PR domain-containing protein 12, PRDM12, PFM9|
|Target/Specificity||This PRDM12 antibody was raised suing purified recombinant GST fusion protein encoding human PRDM12.|
|Format||Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PRDM12 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Involved in the positive regulation of histone H3-K9 dimethylation.|
|Tissue Location||Not found in adult tissues except in dorsal root ganglia.|
Provided below are standard protocols that you may find useful for product applications.
SET domains and histone methylation. Xiao B, et al. Curr Opin Struct Biol, 2003 Dec. PMID 14675547.
A potential role for PRDM12 in the pathogenesis of chronic myeloid leukaemia with derivative chromosome 9 deletion. Reid AG, et al. Leukemia, 2004 Jan. PMID 14523459.
The prototypical 4.1R-10-kDa domain and the 4.1g-10-kDa paralog mediate fodrin-actin complex formation. Kontrogianni-Konstantopoulos A, et al. J Biol Chem, 2001 Jun 8. PMID 11274145.
The yin-yang of PR-domain family genes in tumorigenesis. Jiang GL, et al. Histol Histopathol, 2000 Jan. PMID 10668202.