This gene encodes a member of the FXYD family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The protein encoded by this gene is a plasma membrane substrate for several kinases, including protein kinase A, protein kinase C, NIMA kinase, and myotonic dystrophy kinase. It is thought to form an ion channel or regulate ion channel activity and act as an accessory protein of Na,K-ATPase. Alternatively spliced transcript variants have been described.
Phospholemman and beta-adrenergic stimulation in the heart. Wang J, et al. Am J Physiol Heart Circ Physiol, 2010 Mar. PMID 20008271.
Extracellular potassium dependence of the Na+-K+-ATPase in cardiac myocytes: isoform specificity and effect of phospholemman. Han F, et al. Am J Physiol Cell Physiol, 2009 Sep. PMID 19570895.
FXYD1, a modulator of Na,K-ATPase activity, facilitates female sexual development by maintaining gonadotrophin-releasing hormone neuronal excitability. Garcia-Rudaz C, et al. J Neuroendocrinol, 2009 Feb. PMID 19187398.
Cell volume control in phospholemman (PLM) knockout mice: do cardiac myocytes demonstrate a regulatory volume decrease and is this influenced by deletion of PLM? Bell JR, et al. Exp Physiol, 2009 Mar. PMID 19074587.
Regulation of cardiac myocyte contractility by phospholemman: Na+/Ca2+ exchange versus Na+ -K+ -ATPase. Song J, et al. Am J Physiol Heart Circ Physiol, 2008 Oct. PMID 18708446.