|Application ||WB, E|
|Clone Names||20CT22.214.171.124 / 20CT126.96.36.199|
|Other Names||Dual specificity protein phosphatase H1, 313-, Late protein H1, H1L|
|Target/Specificity||Purified recombinant H1L fusion protein was used to produced this monoclonal antibody.|
|Format||Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||H1L Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Serine/Tyrosine phosphatase which down-regulates cellular antiviral response by dephosphorylating activated host STAT1 and blocking interferon (IFN)-stimulated innate immune responses. Dephosphorylates the A17 protein (By similarity).|
|Cellular Location||Virion. Host cytoplasm. Note=Approximately 200 molecules of H1 are packaged within the virion and are essential for the viability of the virus.|
This Protein shows activity toward tyrosine-protein phosphate as well as with serine-protein phosphate.
Goebel S.J., Virology 179:247-266(1990). Goebel S.J., Virology 179:517-563(1990).